PlantPathoEffV1, Main, Exploration, bibRecord, 000216

An orphan protein of Fusarium graminearum modulates host immunity by mediating proteasomal degradation of TaSnRK1α.

Identifieur interne : 000216 ( Main/Exploration ); précédent : 000215; suivant : 000217

An orphan protein of Fusarium graminearum modulates host immunity by mediating proteasomal degradation of TaSnRK1α.

Source :

Nature communications [ 2041-1723 ] ; 2020.

RBID : pubmed:32873802

Descripteurs français

English descriptors

KwdEn :
- Disease Resistance (MeSH), Fungal Proteins (metabolism), Fusarium (immunology), Fusarium (metabolism), Fusarium (pathogenicity), Host-Pathogen Interactions (immunology), Plant Diseases (immunology), Plant Diseases (microbiology), Plant Proteins (genetics), Plant Proteins (immunology), Plant Proteins (metabolism), Plants, Genetically Modified (MeSH), Proteasome Endopeptidase Complex (metabolism), Protein-Serine-Threonine Kinases (genetics), Protein-Serine-Threonine Kinases (immunology), Protein-Serine-Threonine Kinases (metabolism), Proteolysis (MeSH), Trichothecenes (metabolism), Triticum (immunology), Triticum (microbiology), Virulence Factors (metabolism).
MESH :
- chemical , genetics : Plant Proteins, Protein-Serine-Threonine Kinases.
- chemical , immunology : Plant Proteins, Protein-Serine-Threonine Kinases.
- chemical , metabolism : Fungal Proteins, Plant Proteins, Proteasome Endopeptidase Complex, Protein-Serine-Threonine Kinases, Trichothecenes, Virulence Factors.
- immunology : Fusarium, Host-Pathogen Interactions, Plant Diseases, Triticum.
- metabolism : Fusarium.
- microbiology : Plant Diseases, Triticum.
- pathogenicity : Fusarium.
- Disease Resistance, Plants, Genetically Modified, Proteolysis.

Abstract

Fusarium graminearum is a causal agent of Fusarium head blight (FHB) and a deoxynivalenol (DON) producer. In this study, OSP24 is identified as an important virulence factor in systematic characterization of the 50 orphan secreted protein (OSP) genes of F. graminearum. Although dispensable for growth and initial penetration, OSP24 is important for infectious growth in wheat rachis tissues. OSP24 is specifically expressed during pathogenesis and its transient expression suppresses BAX- or INF1-induced cell death. Osp24 is translocated into plant cells and two of its 8 cysteine-residues are required for its function. Wheat SNF1-related kinase TaSnRK1α is identified as an Osp24-interacting protein and shows to be important for FHB resistance in TaSnRK1α-overexpressing or silencing transgenic plants. Osp24 accelerates the degradation of TaSnRK1α by facilitating its association with the ubiquitin-26S proteasome. Interestingly, TaSnRK1α also interacts with TaFROG, an orphan wheat protein induced by DON. TaFROG competes against Osp24 for binding with the same region of TaSnRKα and protects it from degradation. Overexpression of TaFROG stabilizes TaSnRK1α and increases FHB resistance. Taken together, Osp24 functions as a cytoplasmic effector by competing against TaFROG for binding with TaSnRK1α, demonstrating the counteracting roles of orphan proteins of both host and fungal pathogens during their interactions.

DOI: 10.1038/s41467-020-18240-y
PubMed: 32873802
PubMed Central: PMC7462860

Affiliations:

République populaire de Chine, États-Unis

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en">An orphan protein of Fusarium graminearum modulates host immunity by mediating proteasomal degradation of TaSnRK1α.</title>
<author><name sortKey="Jiang, Cong" sort="Jiang, Cong" uniqKey="Jiang C" first="Cong" last="Jiang">Cong Jiang</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Crop Stress Biology for Arid Areas and NWAFU-Purdue Joint Research Center, College of Plant Protection, Northwest A&F University, 712100, Yangling, Shaanxi, China.</nlm:affiliation>
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<country xml:lang="fr">République populaire de Chine</country>
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<author><name sortKey="Wang, Wei" sort="Wang, Wei" uniqKey="Wang W" first="Wei" last="Wang">Wei Wang</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Crop Stress Biology for Arid Areas and NWAFU-Purdue Joint Research Center, College of Plant Protection, Northwest A&F University, 712100, Yangling, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
</affiliation>
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<author><name sortKey="Zhang, Qiang" sort="Zhang, Qiang" uniqKey="Zhang Q" first="Qiang" last="Zhang">Qiang Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Crop Stress Biology for Arid Areas and NWAFU-Purdue Joint Research Center, College of Plant Protection, Northwest A&F University, 712100, Yangling, Shaanxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Crop Stress Biology for Arid Areas and NWAFU-Purdue Joint Research Center, College of Plant Protection, Northwest A&F University, 712100, Yangling, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
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<author><name sortKey="Yan, Min" sort="Yan, Min" uniqKey="Yan M" first="Min" last="Yan">Min Yan</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Crop Stress Biology for Arid Areas and NWAFU-Purdue Joint Research Center, College of Plant Protection, Northwest A&F University, 712100, Yangling, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
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<author><name sortKey="Zhu, Gengrui" sort="Zhu, Gengrui" uniqKey="Zhu G" first="Gengrui" last="Zhu">Gengrui Zhu</name>
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<wicri:noRegion>Shaanxi</wicri:noRegion>
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<author><name sortKey="Huang, Panpan" sort="Huang, Panpan" uniqKey="Huang P" first="Panpan" last="Huang">Panpan Huang</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Crop Stress Biology for Arid Areas and NWAFU-Purdue Joint Research Center, College of Plant Protection, Northwest A&F University, 712100, Yangling, Shaanxi, China.</nlm:affiliation>
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<author><name sortKey="Liu, Huiquan" sort="Liu, Huiquan" uniqKey="Liu H" first="Huiquan" last="Liu">Huiquan Liu</name>
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<author><name sortKey="Xu, Jin Rong" sort="Xu, Jin Rong" uniqKey="Xu J" first="Jin-Rong" last="Xu">Jin-Rong Xu</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Disease Resistance (MeSH)</term>
<term>Fungal Proteins (metabolism)</term>
<term>Fusarium (immunology)</term>
<term>Fusarium (metabolism)</term>
<term>Fusarium (pathogenicity)</term>
<term>Host-Pathogen Interactions (immunology)</term>
<term>Plant Diseases (immunology)</term>
<term>Plant Diseases (microbiology)</term>
<term>Plant Proteins (genetics)</term>
<term>Plant Proteins (immunology)</term>
<term>Plant Proteins (metabolism)</term>
<term>Plants, Genetically Modified (MeSH)</term>
<term>Proteasome Endopeptidase Complex (metabolism)</term>
<term>Protein-Serine-Threonine Kinases (genetics)</term>
<term>Protein-Serine-Threonine Kinases (immunology)</term>
<term>Protein-Serine-Threonine Kinases (metabolism)</term>
<term>Proteolysis (MeSH)</term>
<term>Trichothecenes (metabolism)</term>
<term>Triticum (immunology)</term>
<term>Triticum (microbiology)</term>
<term>Virulence Factors (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Facteurs de virulence (métabolisme)</term>
<term>Fusarium (immunologie)</term>
<term>Fusarium (métabolisme)</term>
<term>Fusarium (pathogénicité)</term>
<term>Interactions hôte-pathogène (immunologie)</term>
<term>Maladies des plantes (immunologie)</term>
<term>Maladies des plantes (microbiologie)</term>
<term>Proteasome endopeptidase complex (métabolisme)</term>
<term>Protein-Serine-Threonine Kinases (génétique)</term>
<term>Protein-Serine-Threonine Kinases (immunologie)</term>
<term>Protein-Serine-Threonine Kinases (métabolisme)</term>
<term>Protéines fongiques (métabolisme)</term>
<term>Protéines végétales (génétique)</term>
<term>Protéines végétales (immunologie)</term>
<term>Protéines végétales (métabolisme)</term>
<term>Protéolyse (MeSH)</term>
<term>Résistance à la maladie (MeSH)</term>
<term>Trichothécènes (métabolisme)</term>
<term>Triticum (immunologie)</term>
<term>Triticum (microbiologie)</term>
<term>Végétaux génétiquement modifiés (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Plant Proteins</term>
<term>Protein-Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Plant Proteins</term>
<term>Protein-Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Fungal Proteins</term>
<term>Plant Proteins</term>
<term>Proteasome Endopeptidase Complex</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Trichothecenes</term>
<term>Virulence Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protein-Serine-Threonine Kinases</term>
<term>Protéines végétales</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Fusarium</term>
<term>Interactions hôte-pathogène</term>
<term>Maladies des plantes</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Protéines végétales</term>
<term>Triticum</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Fusarium</term>
<term>Host-Pathogen Interactions</term>
<term>Plant Diseases</term>
<term>Triticum</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Fusarium</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Maladies des plantes</term>
<term>Triticum</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Plant Diseases</term>
<term>Triticum</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteurs de virulence</term>
<term>Fusarium</term>
<term>Proteasome endopeptidase complex</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Protéines fongiques</term>
<term>Protéines végétales</term>
<term>Trichothécènes</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Fusarium</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Fusarium</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Disease Resistance</term>
<term>Plants, Genetically Modified</term>
<term>Proteolysis</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Protéolyse</term>
<term>Résistance à la maladie</term>
<term>Végétaux génétiquement modifiés</term>
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<front><div type="abstract" xml:lang="en">Fusarium graminearum is a causal agent of Fusarium head blight (FHB) and a deoxynivalenol (DON) producer. In this study, OSP24 is identified as an important virulence factor in systematic characterization of the 50 orphan secreted protein (OSP) genes of F. graminearum. Although dispensable for growth and initial penetration, OSP24 is important for infectious growth in wheat rachis tissues. OSP24 is specifically expressed during pathogenesis and its transient expression suppresses BAX- or INF1-induced cell death. Osp24 is translocated into plant cells and two of its 8 cysteine-residues are required for its function. Wheat SNF1-related kinase TaSnRK1α is identified as an Osp24-interacting protein and shows to be important for FHB resistance in TaSnRK1α-overexpressing or silencing transgenic plants. Osp24 accelerates the degradation of TaSnRK1α by facilitating its association with the ubiquitin-26S proteasome. Interestingly, TaSnRK1α also interacts with TaFROG, an orphan wheat protein induced by DON. TaFROG competes against Osp24 for binding with the same region of TaSnRKα and protects it from degradation. Overexpression of TaFROG stabilizes TaSnRK1α and increases FHB resistance. Taken together, Osp24 functions as a cytoplasmic effector by competing against TaFROG for binding with TaSnRK1α, demonstrating the counteracting roles of orphan proteins of both host and fungal pathogens during their interactions.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32873802</PMID>
<DateCompleted><Year>2020</Year>
<Month>09</Month>
<Day>21</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>09</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2041-1723</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>11</Volume>
<Issue>1</Issue>
<PubDate><Year>2020</Year>
<Month>09</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>Nature communications</Title>
<ISOAbbreviation>Nat Commun</ISOAbbreviation>
</Journal>
<ArticleTitle>An orphan protein of Fusarium graminearum modulates host immunity by mediating proteasomal degradation of TaSnRK1α.</ArticleTitle>
<Pagination><MedlinePgn>4382</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1038/s41467-020-18240-y</ELocationID>
<Abstract><AbstractText>Fusarium graminearum is a causal agent of Fusarium head blight (FHB) and a deoxynivalenol (DON) producer. In this study, OSP24 is identified as an important virulence factor in systematic characterization of the 50 orphan secreted protein (OSP) genes of F. graminearum. Although dispensable for growth and initial penetration, OSP24 is important for infectious growth in wheat rachis tissues. OSP24 is specifically expressed during pathogenesis and its transient expression suppresses BAX- or INF1-induced cell death. Osp24 is translocated into plant cells and two of its 8 cysteine-residues are required for its function. Wheat SNF1-related kinase TaSnRK1α is identified as an Osp24-interacting protein and shows to be important for FHB resistance in TaSnRK1α-overexpressing or silencing transgenic plants. Osp24 accelerates the degradation of TaSnRK1α by facilitating its association with the ubiquitin-26S proteasome. Interestingly, TaSnRK1α also interacts with TaFROG, an orphan wheat protein induced by DON. TaFROG competes against Osp24 for binding with the same region of TaSnRKα and protects it from degradation. Overexpression of TaFROG stabilizes TaSnRK1α and increases FHB resistance. Taken together, Osp24 functions as a cytoplasmic effector by competing against TaFROG for binding with TaSnRK1α, demonstrating the counteracting roles of orphan proteins of both host and fungal pathogens during their interactions.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jiang</LastName>
<ForeName>Cong</ForeName>
<Initials>C</Initials>
<Identifier Source="ORCID">0000-0002-5634-3200</Identifier>
<AffiliationInfo><Affiliation>State Key Laboratory of Crop Stress Biology for Arid Areas and NWAFU-Purdue Joint Research Center, College of Plant Protection, Northwest A&F University, 712100, Yangling, Shaanxi, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Botany and Plant Pathology, Purdue University, West Lafayette, IN, 47907, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hei</LastName>
<ForeName>Ruonan</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Crop Stress Biology for Arid Areas and NWAFU-Purdue Joint Research Center, College of Plant Protection, Northwest A&F University, 712100, Yangling, Shaanxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Yang</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Crop Stress Biology for Arid Areas and NWAFU-Purdue Joint Research Center, College of Plant Protection, Northwest A&F University, 712100, Yangling, Shaanxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Shijie</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>School of Life Sciences, Zhengzhou University, 450001, Zhengzhou, Henan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Qinhu</ForeName>
<Initials>Q</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Crop Stress Biology for Arid Areas and NWAFU-Purdue Joint Research Center, College of Plant Protection, Northwest A&F University, 712100, Yangling, Shaanxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Wei</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Crop Stress Biology for Arid Areas and NWAFU-Purdue Joint Research Center, College of Plant Protection, Northwest A&F University, 712100, Yangling, Shaanxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Qiang</ForeName>
<Initials>Q</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Crop Stress Biology for Arid Areas and NWAFU-Purdue Joint Research Center, College of Plant Protection, Northwest A&F University, 712100, Yangling, Shaanxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yan</LastName>
<ForeName>Min</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Crop Stress Biology for Arid Areas and NWAFU-Purdue Joint Research Center, College of Plant Protection, Northwest A&F University, 712100, Yangling, Shaanxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhu</LastName>
<ForeName>Gengrui</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Crop Stress Biology for Arid Areas and NWAFU-Purdue Joint Research Center, College of Plant Protection, Northwest A&F University, 712100, Yangling, Shaanxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Panpan</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Crop Stress Biology for Arid Areas and NWAFU-Purdue Joint Research Center, College of Plant Protection, Northwest A&F University, 712100, Yangling, Shaanxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Huiquan</ForeName>
<Initials>H</Initials>
<Identifier Source="ORCID">0000-0002-4723-845X</Identifier>
<AffiliationInfo><Affiliation>State Key Laboratory of Crop Stress Biology for Arid Areas and NWAFU-Purdue Joint Research Center, College of Plant Protection, Northwest A&F University, 712100, Yangling, Shaanxi, China. liuhuiquan@nwsuaf.edu.cn.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xu</LastName>
<ForeName>Jin-Rong</ForeName>
<Initials>JR</Initials>
<Identifier Source="ORCID">0000-0001-5999-5004</Identifier>
<AffiliationInfo><Affiliation>Department of Botany and Plant Pathology, Purdue University, West Lafayette, IN, 47907, USA. jinrong@purdue.edu.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>09</Month>
<Day>01</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Nat Commun</MedlineTA>
<NlmUniqueID>101528555</NlmUniqueID>
<ISSNLinking>2041-1723</ISSNLinking>
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</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010940">Plant Proteins</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014255">Trichothecenes</NameOfSubstance>
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<Chemical><RegistryNumber>EC 2.7.1.-</RegistryNumber>
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<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
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<Chemical><RegistryNumber>EC 3.4.25.1</RegistryNumber>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D060467" MajorTopicYN="N">Disease Resistance</DescriptorName>
</MeshHeading>
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</MeshHeading>
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<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
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<MeshHeading><DescriptorName UI="D017346" MajorTopicYN="N">Protein-Serine-Threonine Kinases</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D059748" MajorTopicYN="N">Proteolysis</DescriptorName>
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<MeshHeading><DescriptorName UI="D014255" MajorTopicYN="N">Trichothecenes</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
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<MeshHeading><DescriptorName UI="D014908" MajorTopicYN="N">Triticum</DescriptorName>
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<MeshHeading><DescriptorName UI="D037521" MajorTopicYN="N">Virulence Factors</DescriptorName>
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<Month>02</Month>
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	Serveur d'exploration sur les effecteurs de phytopathogènes
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An orphan protein of Fusarium graminearum modulates host immunity by mediating proteasomal degradation of TaSnRK1α.

An orphan protein of Fusarium graminearum modulates host immunity by mediating proteasomal degradation of TaSnRK1α.

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